Thursday, January 5, 2012

A shot of young stem cells made rapidly aging mice live longer and healthier

Tuesday, January 3, 2012

Mice bred to age too quickly seemed to have sipped from the fountain of youth after scientists at the University of Pittsburgh School of Medicine injected them with stem cell-like progenitor cells derived from the muscle of young, healthy animals. Instead of becoming infirm and dying early as untreated mice did, animals that got the stem/progenitor cells improved their health and lived two to three times longer than expected, according to findings published in the Jan. 3 edition of Nature Communications.

Previous research has revealed stem cell dysfunction, such as poor replication and differentiation, in a variety of tissues in old age, but it's not been clear whether that loss of function contributed to the aging process or was a result of it, explained senior investigators Johnny Huard, Ph.D., and Laura Niedernhofer, M.D., Ph.D. Dr. Huard is professor in the Departments of Orthopaedic Surgery and of Microbiology and Molecular Genetics, Pitt School of Medicine, and director of the Stem Cell Research Center at Pitt and Children's Hospital of PIttsburgh of UPMC. Dr. Niedernhofer is associate professor in Pitt's Department of Microbiology and Molecular Genetics and the University of Pittsburgh Cancer Institute (UPCI).

"Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals," Dr. Niedernhofer said. "That tells us that stem cell dysfunction is a cause of the changes we see with aging."

Their team examined a stem/progenitor cell population derived from the muscle of progeria mice and found that compared to those from normal rodents, the cells were fewer in number, did not replicate as often, didn't differentiate as readily into specialized cells and were impaired in their ability to regenerate damaged muscle. The same defects were discovered in the stem/progenitor cells isolated from very old mice.

"We wanted to see if we could rescue these rapidly aging animals, so we injected stem/progenitor cells from young, healthy mice into the abdomens of 17-day-old progeria mice," Dr. Huard said. "Typically the progeria mice die at around 21 to 28 days of age, but the treated animals lived far longer ? some even lived beyond 66 days. They also were in better general health."

As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. Affected mice that got a shot of stem cells just before showing the first signs of aging were more like normal mice, and they grew almost as large. Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren't detected in those tissues.

In fact, the cells didn't migrate to any particular tissue after injection into the abdomen.

"This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue," Dr. Niedernhofer said. "In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells, and the unhealthy cells functionally improved."

Animals that age normally were not treated with stem/progenitor cells, but the provocative findings urge further research, she added. They hint that it might be possible one day to forestall the biological declines associated with aging by delivering a shot of youthful vigor, particularly if specific rejuvenating proteins or molecules produced by the stem cells could be identified and isolated.

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University of Pittsburgh Schools of the Health Sciences: http://www.upmc.com/Pages/default.aspx

Thanks to University of Pittsburgh Schools of the Health Sciences for this article.

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Source: http://www.labspaces.net/116373/A_shot_of_young_stem_cells_made_rapidly_aging_mice_live_longer_and_healthier

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Life Insurance Policies for Parents

In most cases, you can purchase life insurance policies for your parents.? The most popular types of policies for parents are term life insurance, whole life insurance, and second to die policies.? Here is some of the information you?ll need to know if you are a child searching for your parent/s.

Ownership of Policy: One of the first things I ask the child when he/she calls me is who would be the owner and payor of the policy.? In some cases, children are simply calling on behalf of their parents who are not internet savvy, and are doing nothing more than helping their parents, who don?t know how to buy life insurance, with the quoting and application process, but that the parents will be paying for the policy.

In other cases, you have children who will be the owner of the policy, pay the premiums, and also be the beneficiary of the death proceeds.? Usually this is okay as long as the child can prove an insurable interest. This is 100% legal, but will require approval by the insurance company.

An insurable interest means that the child would be somehow financially affected by the death of his or her parents.? So if your parents have a big mortgage on their home, and you don?t want to inherit their debt, life insurance may be in order.? Or if you are responsible for your parents funeral and burial arrangements, life insurance may be used for this.

How Much Life Insurance Can I Purchase on My Parents?

The trick is to apply for a reasonable amount of coverage to protect you from financial hardship.? The idea is to be indemnified, or made whole? not to get rich off your parents? death.? So if your 81 year old mother is living with you, and lives off social security, and provides no financial benefit to your family, and has no debt, you would not, for example, be approved for a 1 million dollar life insurance policy.

In most cases, a $100,000 life insurance policy for parents is approved without hitting any barriers.? Beyond this, financial justification will be required.

Requirements to Purchase Life Insurance on Your Parents

Your parents will first, need to be aware that the policy is being taken out on them.? It?s impossible for them not to know, since they will need to sign the application as the ?primary insured? or ?primary applicant?.? Most policies will also require a medical exam.? It?s really not too complicated.? You just complete an application, (sometimes the medical exam), and then wait for approval.

Types of Life Insurance for Parents:

Term is the most common type of insurance sold today, because it offers the lowest cost for level premiums during the duration of the term.? You must consider your parents? life expectancy, however, if you?re considering term.? You don?t want to get a 10 year term if you actually need the coverage for as long as they live.

In the latter case, whole life insurance, or its little sister, universal life insurance (a lower cost policy offering coverage for life), may be more suitable for you.? You can get quotes in our quote form on the right to age 100 or 121, which are guaranteed universal life insurance policies.

Another popular choice for parents is a second-to-die policy.? As the name indicates, this policy only pays out one death benefit, upon death of the second parent.? This type of insurance is popular in combination with estate planning and life insurance trusts, but not necessarily.

For the best term life insurance prices on your parents, or any other type of life insurance, it?s best to speak with a knowledgeable professional, who can discuss your options and pricing with you.? You may get a quote using our form on the right or by calling us at 877-996-9383.

Source: http://termlifeinsurancemales.com/types-of-life-insurance/life-insurance-policies-for-parents/

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Union Line Says ?Bah Humbug? to Occupiers

Occupy Memphis OccupySupply

Occupy Memphis in Union Line jackets

Occupy Supply has spent literally tens of thousands of dollars on union made Union Line goods over the course of the past few months. ?Their quilt lined work jackets, blankets and fleece ?have become ubiquitous at over 70 occupations across the country, and occupiers have been asking for them every day as the weather gets colder.

Back on November 15, we wrote a purchase order for 250 more jackets that we placed through our embroiderer, but Union Line owner Dave Rubin said they couldn?t ship until December 31 because they were working on a large contract for military pants. ?We said okay, and put the jackets on the distribution schedule for the first week in January.

As many people know, we had problems with our embroiderer (who also did our glove and sock imprints) and were literally down to the wire at Christmas fulfilling orders we sold through the Occupy Supply online store. So 11 days ago I contacted Union Line to let them know we wouldn?t be working with American Unions any more, but were still interested in purchasing from them.

It took 11 days for them to figure out who we were, and today they finally emailed us saying that if we wanted to do business with them, we had to go through the embroiderer. ?Since we?ve already incurred tremendous expense making up for those mistakes, that?s not going to happen. ?They won?t say what?s happening with the jackets. I imagine that got screwed up too or I?d be looking at UPS tracking numbers instead of getting blow-off emails.

Anyway, all of this is by way of saying that we won?t be sending the Union Line jackets out to the occupations this week as we?d planned. ?Fortunately we didn?t sit on our thumbs for the past 11 days, and have been talking with other American manufacturers in case Union Line fell through. We?ve already sent other goods to keep Occupy Erie warm, who have been raided 7 times and still keep coming back.

There are certainly other terrific American made outerwear companies and they?re all quite anxious to have our business, but we have always gone out of our way to work with union manufacturers when we can. ?If Union Line ever gets their act together and provides us with the reliability and support we need in order to supply the occupiers, we?ll revisit things. ?But for now, we?re simply not willing to let people freeze in order to work with them, so we?ll be moving on.

Donate to Occupy Supply. 100% of all donations go to purchasing and distributing supplies to occupations across the country.

Source: http://feedproxy.google.com/~r/firedoglake/fdl/~3/JjZbI1OLers/

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Wednesday, January 4, 2012

Insight: Memo to Eddie Lampert - Dump Kmart (Reuters)

(Reuters) ? If hedge fund manager Eddie Lampert wants to save one of the oldest retail empires in the United States, he should consider shutting down Sears Holdings Corp's (SHLD.O) Kmart discount chain and focus on revamping its Sears department stores.

Such is the advice of half a dozen retail executives and restructuring experts who have watched the company's sales shrink every year since 2005, when Lampert formed Sears Holdings by combining two of the most iconic American chains in an $11 billion deal.

After a dismal showing this holiday season due to dowdy merchandise, run-down stores and a reputation for poor service compared with rivals such as Macy's (M.N) and Target (TGT.N), the retailer last week said it would close 100 to 120 of its 3,500 U.S. stores. The news wiped more than a quarter off Sears Holdings' market value, which now stands at just $3.4 billion.

The company needs to take much more radical action to turn around its business, the experts said, pointing to 18 straight quarters of sales declines and Lampert's propensity to spend company cash on buying back shares instead of upgrading stores. His ESL Investments Inc owns 45 percent of Sears Holdings.

"Trimming down a hundred stores is like rearranging deck chairs on the Titanic," said Craig Johnson, president of retail strategy and consulting firm Customer Growth Partners, whose clients include J.C. Penney Co Inc (JCP.N) and Toys R Us. "This is a company that needs not just cosmetic surgery, not just minor surgery, but radical surgery."

Johnson and others said Sears Holdings should close as many as 1,000 stores to cut costs and recoup what it can from selling off inventory and related real estate. Then, it needs to significantly revamp its remaining stores and expand its online business to reverse its years long decline.

Such a culling would be very painful, likely resulting in layoffs for tens of thousands of the company's 280,000-strong U.S. workforce and loss of the major retail store in some communities, according to retail specialists.

Once the largest U.S. discount chain, Kmart has declined over the years as it has been unable to keep up with Wal-Mart's (WMT.N) low prices and Target's more upscale though still affordable offerings. Kmart went bankrupt nearly a decade ago and never fully recovered -- its 2010 sales of $15.6 billion were only about 5 percent of Wal-Mart's U.S. sales.

"In a world that has Wal-Mart and Target, there is really no need for a Kmart," said Roger Goddu, who was CEO of the Montgomery Ward department store chain, which went out of business in 2001.

"The one I would choose to save is Sears," said Goddu, now a partner in private equity firm Brentwood Associates.

Kmart accounted for about 36 percent of the company's sales in 2010 but only 32 percent of gross profit, reflecting the discount retailer's thinner margins compared with Sears. Restructuring experts said it was difficult to estimate how much Kmart would be worth if it was liquidated because the company does not break out inventory by business unit, and the value of its roughly 1,300 stores would depend on when leases expire.

Sears Holdings declined to comment specifically on the future of Kmart, but said the company was an "asset rich enterprise" with well over $3.5 billion of liquidity.

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Sears recent store closures http://link.reuters.com/dax75s

Top five holders of Sears: http://link.reuters.com/wuq75s

Sears vs. competitors http://link.reuters.com/req75s

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HISTORIC BRAND

For those trying to predict the future of Sears Holdings, one key date is February 23, when the company will report annual results. Lampert typically publishes a letter to shareholders at around that time.

Investors lost 56.6 percent on their Sears' stock last year. It hit $193.98 in April 2007, but ended 2011 at just $31.78.

Sears was once one of the most successful U.S. retailers with a history going back to 1886, when Richard Sears began to sell watches as a train station agent in North Redwood, Minnesota. Its sprawling empire had included a radio station in Chicago, Allstate Insurance Co, and Chicago's Sears Tower, the world's tallest building when it was completed in 1973.

The department stores were beloved by generations of Kenmore appliance buyers, while the do-it-yourself crowd scooped up Sears' Craftsman tools. But the company has let its stores deteriorate over the years, say critics, who also faulted poor locations and ho-hum merchandise.

Sears Holdings is now the tenth largest U.S. retailer, with annual sales of $43.3 billion in 2010, down from $53 billion in 2006. Analysts expect it to post an annual loss for the first time in 2011, as their average estimate for fourth quarter net profit of $105 million will not fully offset the $743 million loss that it reported for the first nine months.

Sears Holdings worried Wall Street last week by announcing a 5.2 percent drop in sales at established stores in the 8 weeks leading up to Christmas. It also said that it tapped its credit line, something that alarmed investors since retailers are typically flush with cash during the holiday season.

Fitch Ratings responded by cutting Sears Holdings' credit rating to CCC from B, and Standard & Poor's put its rating on review for a possible downgrade. The cost of insuring Sears Holdings' debt rose as investors saw higher risks of default.

Fitch saw rising risk that Sears Holdings' earnings before interest, tax, depreciation and amortization (EBITDA) could turn negative in 2012, and said it may need to restructure.

"If Sears is unable to access the capital markets or find other adequate sources of availability, and EBITDA remains at the current rate or lower, there is a heightened risk of restructuring over the next 24 months," Fitch said. A CCC rating is defined by Fitch as indicating substantial credit risk, with default a real possibility.

When asked to comment on the company's financial position, Sears Holdings spokesman Chris Brathwaite said: "There's a considerable difference between disappointing operating performance and liquidity."

He noted that Sears Holdings had roughly $700 million in cash and $2.9 billion available on its credit facilities. It also has historically had between $8 billion and $10 billion of inventory and a substantial real estate portfolio, he added.

VENDORS KEY

A Sears Holdings' collapse is not seen likely in the near future. But that could change if key vendors lose faith and demand cash on delivery, decide to ship in smaller quantities, or ask for letters of credit, according to bankruptcy experts.

"The hurdle is going to be when one of the suppliers for a category that is important to them says we want letters of credit to back our receivables, at which point the unused bank lines get used very fast," said John Hempton, chief investment officer of a small hedge fund, Bronte Capital, in Australia. He has a short position on Sears.

Whirlpool Corp (WHR.N) and LG Electronics Inc (066570.KS) said there were no changes in their business ties with Sears and declined to comment on payment terms. Other suppliers General Electric Co (GE.N), Newell Rubbermaid Inc (NWL.N) and Stanley Black and Decker Inc (SWK.N) declined to comment.

"While it's clear that Sears has issues to tackle, they remain a trusted partner," said Jay Vandenbree, senior vice president, LG Electronics USA.

Whirlpool Corp (WHR.N) spokeswoman Kristine Vernier said, "We have had a long history with Sears and expect to continue a productive relationship going forward."

Turnaround expert Gene Baldwin of CRG Partners, a restructuring firm, said that if Sears Holdings' sales continue to decline, large vendors, particularly in consumer electronics, will tighten credit to the company within a couple of years.

"One day, one of the large vendors will say: 'You know, I don't believe this story any more' ... and that will start a snowball of vendor activity," he said.

While he called the situation at Sears "very dire," others are more optimistic about the retailer, saying it can be revived if Lampert brings in a top executive with extensive retail experience. Since he owns nearly half of Sears, Lampert has more reason than most chairmen to avoid bankruptcy.

WANTED: RETAIL GENIUS

Lampert has been criticized for tumult in the executive suite. The retailer in February named Lou D'Ambrosio as its CEO after a three-year search, appointing a technology executive with no retail experience. Sears also appointed a new chief financial officer in the past year, and lost its marketing chief at the start of the holiday season.

Sears could use the Midas touch of someone like Mickey Drexler, a legend in the industry for building up the Gap brand in the 1990's and working his magic at J. Crew where he has been CEO since 2003, said retail consultant Mark Freiman of Focus Management Group, a financial advisory and restructuring firm.

"They have got some iconic brands that if they had the capital behind them and the right merchants in the company, they could be turned around," said Freiman, who was the chief executive of a franchise chain of retail Hallmark stores.

Some analysts said Lampert's tight control over the company made it less attractive to top talent, and it would be difficult for Sears to land someone like Apple Inc's (AAPL.O) ex-retail chief Ron Johnson who joined J.C. Penney last year as its CEO.

One area which retail experts say Sears has done well on is its website Sears.com, considered to be among the best operated by department stores. But they say the online brand has been damaged by shabby bricks-and-mortar stores.

Sears Holdings spent $441 million on capital expenditure in 2010, which includes spending on technology as well as remodeling stores. In comparison, Macy's spent $505 million and it has only 850 stores.

"It's almost a white flag - by letting your stores degrade, you're saying you're not planning to stay long term," said David Berliner, a partner in BDO Consulting's restructuring practice.

Going back to fiscal 2006, Sears Holdings has spent about $2.7 billion on capital expenditures, half the $5.4 billion that the company has spent to buy back shares.

QUESTIONABLE REAL ESTATE

When Lampert engineered the merger, he touted the value of the real estate of the chains. Kmart's stores are primarily leased. About 61 percent of Sears' 800 mall stores are owned, while the others are under longer term leases.

That value has declined over the years as high-profile retail bankruptcies pushed up vacancies in U.S. shopping malls. The average vacancy rate for large U.S. shopping malls hit an 11-year high in the third quarter of 2011.

"There isn't a whole lot of need for empty big boxes right now," said Craig Boucher, another turnaround expert at CRG. "We still have empty Circuit City stores and empty Linens N Things stores out there," he said in reference to two chains that closed in recent years.

(Reporting By Dhanya Skariachan and Phil Wahba in New York. Additional reporting by Ilaina Jonas in New York, Tom Hals in Wilmington Delaware and Nivedita Bhattacharjee in Chicago. Editing by Tiffany Wu and Martin Howell)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20120103/bs_nm/us_sears

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Phone lines down for 1600 Frontier Communications customers in ...

ALOHA -- ?A power outage in Washington County has caused phone outages for about 1,600 Frontier Communications customers Monday evening.

The telecommunications company?s central Aloha office was affected by a power outage, which is not believed to be connected to another power outage in Hillsboro, Washington County Consolidated Communications Agency spokesman Mark Chandler said.

Frontier technicians are on the scene but it?s unknown when the phone lines might be back up.

Chandler urged customers to use a wireless phone in the case of an emergency.

--Sally Ho

Source: http://www.oregonlive.com/aloha/index.ssf/2012/01/phone_outage_for_1600_frontier.html

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NFL star calls rivals 'dirtbags'

Updated?Jan 3, 2012 1:23 PM ET

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The playoff trash talk began early in advance of Sunday's Giants-Falcons Wild Card matchup, with Giants defensive end Justin Tuck calling the Atlanta offensive line "dirtbags."

It is fairly common knowledge throughout the league that the Falcons' offensive line plays to the whistle, and beyond, drawing the ire of many defensive linemen, including the Packers and Lions who complained about dirty tactics this season.

"Most people, you would call them dirtbags," Tuck said. "But it is what it is. We got to make sure we do our job, and if we are doing our job well then they will be upset and they will be trying to do things to get us off our game, and we got to take that as a compliment.

"But in the same sense you got to protect yourself and hopefully the referees have 20-20 vision this week."

Tuck and his teammates on the defensive line are on a roll, with 11 sacks the past two games against the Jets and Cowboys. The Falcons have allowed only 26 sacks of Matt Ryan all season.

Source: http://msn.foxsports.com/nfl/story/new-york-giants-justin-tuck-calls-atlanta-falcons-offensive-line-dirtbags-010312

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Tuesday, January 3, 2012

NHL: Washington 4, Columbus 2

COLUMBUS, Ohio, Dec. 31 (UPI) -- Alex Ovechkin scored twice in the third period Saturday and the Washington Capitals rallied from a late 2-0 deficit to post a 4-2 win over Columbus.

Trailing by a pair of goals entering the final frame, the Caps exploded for four straight scores, ignited when Ovechkin scored unassisted 4:23 into the period.

Alex Semin netted the equalizer 2 1/2 minutes later and Dennis Wideman's goal only 28 seconds after that gave the Caps their first lead.

Ovechkin -- who has scored seven times in eight games -- finished the barrage with a power-play goal at 11:03 and Washington won for the fifth time in those eight contests.

Tomas Vokoun turned aside 35-of-37 shots for the victory.

John Moore and Samuel Pahlsson scored and Steve Mason made 22 saves for the Blue Jackets.

Source: http://c.moreover.com/click/here.pl?r5686505918

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